TY - JOUR T1 - Self-imposed silence: parental antagonism and the evolution of X-chromosome inactivation JF - Evolution Y1 - 2006 A1 - Haig, D. KW - *Biological Evolution KW - *Models, Biological KW - *X Chromosome Inactivation KW - Animals KW - Dosage Compensation, Genetic KW - Female KW - Genes, X-Linked KW - Male AB -

A model is proposed for the evolution of X-chromosome inactivation (XCI) in which natural selection initially favors the silencing of paternally derived alleles of X-linked demand inhibitors. The compensatory upregulation of maternally derived alleles establishes a requirement for monoallelic expression in females. For this reason, XCI is self-reinforcing once established. However, inactivation of a particular X chromosome is not. Random XCI (rXCI) is favored over paternal XCI because rXCI reduces the costs of functional hemizygosity in females. Once present, rXCI favors the evolution of locus-by-locus imprinting of X-linked loci, which creates an evolutionary dynamic in which different chromosomes compete to remain active.

VL - 60 SN - 0014-3820 (Print)0014-3820 (Linking) N1 -

Haig, Davideng2006/04/28 09:00Evolution. 2006 Mar;60(3):440-7.

JO - Evolution; international journal of organic evolutionEvolution; international journal of organic evolution ER -