TY - JOUR T1 - Altercation of generations: genetic conflicts of pregnancy JF - Am J Reprod Immunol Y1 - 1996 A1 - Haig, D. KW - Animals KW - Biological Evolution KW - Embryonic and Fetal Development/*genetics KW - Female KW - Genomic Imprinting/genetics KW - Humans KW - Maternal-Fetal Exchange/*genetics KW - Pregnancy, Animal/*genetics KW - Pregnancy/*genetics AB -

Pregnancy is traditionally viewed as a harmonious collaboration between mother and fetus. From this perspective, viviparity poses a series of problems that maternal and fetal genes work together to solve and the many complications of pregnancy are interpreted as evidence of the malfunctioning of an evolved system or of the failure of natural selection to achieve an adaptive goal. This view fails to recognize aspects of genetic conflict that lie at the heart of gestation. At least three interrelated sources of conflict can be identified: (i) conflict between genes expressed in the mother and genes expressed in the fetus/placenta (parent-offspring conflict); (ii) conflict between maternally-derived and paternally-derived genes within the fetal genome (genomic imprinting); and (iii) conflict between maternal genes that recognize themselves in offspring and the rest of the maternal genome (gestational drive).

VL - 35 SN - 1046-7408 (Print)1046-7408 (Linking) N1 -

Haig, DengReviewDENMARKNew York, N.Y. : 19891996/03/01Am J Reprod Immunol. 1996 Mar;35(3):226-32.

JO - American journal of reproductive immunologyAmerican journal of reproductive immunology ER -