@article {509591,
	title = {Parental modifiers, antisense transcripts and loss of imprinting},
	journal = {Proc Biol Sci},
	volume = {269},
	number = {1502},
	year = {2002},
	note = {<p>Wilkins, Jon FHaig, DavidengResearch Support, Non-U.S. Gov{\textquoteright}tEngland2002/09/28 04:00Proc Biol Sci. 2002 Sep 7;269(1502):1841-6.</p>},
	month = {Sep 7},
	pages = {1841-6},
	abstract = {<p>The kinship theory of genomic imprinting has explained parent-specific gene expression as the outcome of an evolutionary conflict between the two alleles at a diploid locus of an offspring over how much to demand from parents. Previous models have predicted that maternally derived (madumnal) alleles will be silent at demand-enhancing loci, while paternally derived (padumnal) alleles will be silent at demand-suppressing loci, but these models have not considered the evolution of trans-acting modifiers that are expressed in parents and influence imprinted expression in offspring. We show that such modifiers will sometimes be selected to reactivate the silent padumnal allele at a demand-suppressing locus but will not be selected to reactivate the silent madumnal allele at a demand-enhancing locus. Therefore, imprinting of demand-suppressing loci is predicted to be less evolutionarily stable than imprinting of demand-enhancing loci.</p>},
	keywords = {*Genomic Imprinting, Alleles, Animals, Biological Evolution, DNA Methylation, DNA, Antisense/genetics, Female, Gene Silencing, Male, Models, Genetic, Mutation, Transcription, Genetic},
	isbn = {0962-8452 (Print)0962-8452 (Linking)},
	author = {Wilkins, J. F. and Haig, D.}
}
