@article {509471,
	title = {Fitness variation due to sexual antagonism and linkage disequilibrium},
	journal = {Evolution},
	volume = {64},
	number = {12},
	year = {2010},
	note = {<p>Patten, Manus MHaig, DavidUbeda, Franciscoeng2010/08/21 06:00Evolution. 2010 Dec;64(12):3638-42. doi: 10.1111/j.1558-5646.2010.01100.x.</p>},
	month = {Dec},
	pages = {3638-42},
	abstract = {<p>Extensive fitness variation for sexually antagonistic characters has been detected in nature. However, current population genetic theory suggests that sexual antagonism is unlikely to play a major role in the maintenance of variation. We present a two-locus model of sexual antagonism that is capable of explaining greater fitness variance at equilibrium than previous single-locus models. The second genetic locus provides additional fitness variance in two complementary ways. First, linked loci can maintain gene variants that are lost in single-locus models of evolution, expanding the opportunity for polymorphism. Second, linkage disequilibrium results between any two sexually antagonistic genes, producing an excess of high- and low-fitness haplotypes. Our results uncover a unique contribution of conflicting selection pressures to the maintenance of variation, which simpler models that neglect genetic architecture overlook.</p>},
	keywords = {*Genetic Fitness, *Genetic Variation, Animals, Female, Haplotypes, Linkage Disequilibrium, Male, Models, Biological, Polymorphism, Genetic, Sex Characteristics},
	isbn = {1558-5646 (Electronic)0014-3820 (Linking)},
	author = {Patten, M. M. and Haig, D. and Ubeda, F.}
}
