@article {508876,
	title = {Self-imposed silence: parental antagonism and the evolution of X-chromosome inactivation},
	journal = {Evolution},
	volume = {60},
	number = {3},
	year = {2006},
	note = {<p>Haig, Davideng2006/04/28 09:00Evolution. 2006 Mar;60(3):440-7.</p>},
	month = {Mar},
	pages = {440-7},
	abstract = {<p>A model is proposed for the evolution of X-chromosome inactivation (XCI) in which natural selection initially favors the silencing of paternally derived alleles of X-linked demand inhibitors. The compensatory upregulation of maternally derived alleles establishes a requirement for monoallelic expression in females. For this reason, XCI is self-reinforcing once established. However, inactivation of a particular X chromosome is not. Random XCI (rXCI) is favored over paternal XCI because rXCI reduces the costs of functional hemizygosity in females. Once present, rXCI favors the evolution of locus-by-locus imprinting of X-linked loci, which creates an evolutionary dynamic in which different chromosomes compete to remain active.</p>},
	keywords = {*Biological Evolution, *Models, Biological, *X Chromosome Inactivation, Animals, Dosage Compensation, Genetic, Female, Genes, X-Linked, Male},
	isbn = {0014-3820 (Print)0014-3820 (Linking)},
	author = {Haig, D.}
}
