@article {508701,
	title = {Sex-specific parent-of-origin allelic expression in the mouse brain},
	journal = {Science},
	volume = {329},
	number = {5992},
	year = {2010},
	note = {<p>Gregg, ChristopherZhang, JiangwenButler, James EHaig, DavidDulac, CatherineengHoward Hughes Medical Institute/Research Support, Non-U.S. Gov{\textquoteright}tNew York, N.Y.2010/07/10 06:00Science. 2010 Aug 6;329(5992):682-5. doi: 10.1126/science.1190831. Epub 2010 Jul 8.</p>},
	month = {Aug 6},
	pages = {682-5},
	abstract = {<p>Genomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamus, sex-specific imprinted genes were mostly found in females, which suggests parental influence over the hypothalamic function of daughters. We show that interleukin-18, a gene linked to diseases with sex-specific prevalence, is subject to complex, regional, and sex-specific parental effects in the brain. Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease.</p>},
	keywords = {*Alleles, *Epigenesis, Genetic, *Genes, X-Linked, *Genomic Imprinting, *Sex Characteristics, Animals, Crosses, Genetic, Dioxygenases, Female, Gene Expression Profiling, Glutamic Acid/metabolism, Interleukin-18/genetics, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mitochondrial Proteins/genetics, Neurons/metabolism, Oxygenases/genetics, Polymorphism, Single Nucleotide, Prefrontal Cortex/cytology/*metabolism, Preoptic Area/cytology/*metabolism, Ribosomal Proteins/genetics, Succinate Dehydrogenase/genetics, X Chromosome Inactivation},
	isbn = {1095-9203 (Electronic)0036-8075 (Linking)},
	author = {Gregg, C. and Zhang, J. and Butler, J. E. and Haig, D. and Dulac, C.}
}
