@article {509476,
	title = {Sexual and parental antagonism shape genomic architecture},
	journal = {Proc Biol Sci},
	volume = {280},
	number = {1770},
	year = {2013},
	note = {<p>Patten, Manus MUbeda, FranciscoHaig, DavidengEngland2013/09/13 06:00Proc Biol Sci. 2013 Sep 11;280(1770):20131795. doi: 10.1098/rspb.2013.1795. Print 2013 Nov 7.</p>},
	month = {Nov 7},
	pages = {20131795},
	abstract = {<p>Populations with two sexes are vulnerable to a pair of genetic conflicts: sexual antagonism that can arise when alleles have opposing fitness effects on females and males; and parental antagonism that arises when alleles have opposing fitness effects when maternally and paternally inherited. This paper extends previous theoretical work that found stable linkage disequilibrium (LD) between sexually antagonistic loci. We find that LD is also generated between parentally antagonistic loci, and between sexually and parentally antagonistic loci, without any requirement of epistasis. We contend that the LD in these models arises from the admixture of gene pools subject to different selective histories. We also find that polymorphism maintained by parental antagonism at one locus expands the opportunity for polymorphism at a linked locus experiencing parental or sexual antagonism. Taken together, our results predict the chromosomal clustering of loci that segregate for sexually and parentally antagonistic alleles. Thus, genetic conflict may play a role in the evolution of genomic architecture.</p>},
	keywords = {*Genetic Fitness, *Linkage Disequilibrium, *Selection, Genetic, Alleles, Animals, Biological Evolution, Female, Male, Mating Preference, Animal, Models, Genetic, Polymorphism, Genetic},
	isbn = {1471-2954 (Electronic)0962-8452 (Linking)},
	author = {Patten, M. M. and Ubeda, F. and Haig, D.}
}
