@article {508651,
	title = {The evolution of reproduction-related NLRP genes},
	journal = {J Mol Evol},
	volume = {78},
	number = {3-4},
	year = {2014},
	note = {<p>Duenez-Guzman, Edgar AHaig, DavidengHoward Hughes Medical Institute/Research Support, Non-U.S. Gov{\textquoteright}tGermany2014/03/13 06:00J Mol Evol. 2014 Apr;78(3-4):194-201. doi: 10.1007/s00239-014-9614-3. Epub 2014 Mar 11.</p>},
	month = {Apr},
	pages = {194-201},
	abstract = {<p>NLRP proteins are important components of inflammasomes with a major role in innate immunity. A subset of NLRP genes, with unknown functions, are expressed in oocytes and early embryos. Mutations of Nlrp5 in mice are associated with maternal-effect embryonic lethality and mutations of NLRP7 in women are associated with conception of biparental complete hydatidiform moles (biCHMs), suggesting perturbed processes of genomic imprinting. Recessive mutations on NLRP2/7 in humans are associated with reproductive disorders and appear to be induced by a demethylation of the maternal pronucleus. In this study, we find that radiation of NLRP genes occurred before the common ancestor of Afrotheria and Boreoeutheria, with the clade of oocyte-expressed genes originating before the divergence of marsupial and eutherian mammals. There have been multiple independent duplications of NLRP2 genes one of which produced the NLRP7 gene associated with biCHMs.</p>},
	isbn = {1432-1432 (Electronic)0022-2844 (Linking)},
	author = {Duenez-Guzman, E. A. and Haig, D.}
}
